Nuclear receptor liver receptor homolog-1 (LRH-1, <i>NR5A2</i>) is proved to play a positive role in several cancers including breast cancer, pancreatic cancer and intestinal cancer in recent years.
Analysis of breast cancer samples reveals that a high LRH-1 level is inversely correlated with CDKN1A expression in breast cancer patients and is associated with poor prognosis.
The results of this study support the hypothesis that suppression of LRH-1 may potentially be beneficial in the tissue specific regulation of aromatase expression in post menopausal breast cancer.
LRH-1 mRNA expression was low in normal breast tissue but markedly elevated in both breast carcinoma tissue and adipose tissue surrounding the tumor invasion (thereby paralleling aromatase expression).